1. Pilot

Dr. John Watson resumes his medical career as the head of a clinic dedicated to treating rare disorders six months after the death of his friend and partner, Sherlock Holmes, at the hands of Moriarty.

2. Redcoat

Watson and the fellows investigate the perplexing case of a family man with a bullet lodged in his head who insists he is a Scottish soldier and seems to be hiding something nefarious.

3. Wait for the Punchline

Watson and the fellows treat a comedian who collapses at an open mic night, but throughout the case her past is revealed to be much more complex than initially believed.

4. Patient Question Mark

When Sasha discovers a link between her current patient, who has advanced cancers and distinctive lesions on his tongue indicative of Cowden syndrome, and a cadaver she dissected during medical school, the team traces the case to Amish country.

5. The Man with the Glowing Chest

Watson takes a major ethical risk when he decides to treat a sickle cell patient with an unorthodox surgery, and the team faces their own dilemma when they must decide whether to look the other way or help the young woman.

6. The Camgirl Inquiry

Stephens musters the courage to ask Watson to help him when his camgirl suddenly collapses during a video call. He does not know anything about her real life, so the team must act quickly to locate her before it's too late.

7. Teeth Marks

While Watson and the team help a woman whose memory resets every three minutes, Watson struggles with auditory hallucinations and questions whether someone is behind his current decline. Also, Moriarty plots his next move.

8. A Variant of Unknown Significance

Watson runs into brilliant con artist and an old friend of Sherlock Holmes, Irene Adler, when her son Angus is admitted to UHOP for temporary paralysis. The fellows help Watson after he grows fond of Angus and pursue various leads to find a cure to his illness.

9. Take a Family History

Ingrid's lies come back to haunt her when her sister Gigi needs to be treated by the team after she develops side effects to the secret treatments Ingrid put her through. Also, Watson and Mary bond over a tragedy.

10. The Man with the Alien Hand

Watson is thrown into a detective case when he is unsure whether the patient he is treating for one of the most rare ailments in the world, Alien Hand Syndrome, is guilty of pushing his brother in front of a bus to his death.

11. The Dark Day Deduction

Watson confronts a traumatic event from his Army days that still weighs heavily on him when his Army veteran friend’s wife reaches out begging for help when her husband is seemingly having a psychotic break. Meanwhile, Shinwell is asked for one last favor by Moriarty.

12. My Life's Work (1)

When part of the team falls ill after becoming targets of a sinister plot, it becomes an all-hands-on-deck situation to save them before it's too late. Meanwhile, Watson announces a new ambitious project that he has been working on.

13. My Life's Work (2)

Watson and the team are faced with an impossible choice when two lives hang in the balance, but they only have one vial of antidote available. Meanwhile, Shinwell races to help the team, and Watson goes head to head with Moriarty.