Tom Hanks

Dr. Henry Goose / Hotel Manager / Isaac Sachs / Dermot Hoggins / Cavendish Look-a-Like Actor / Zachry

Halle Berry

Native Woman / Jocasta Ayrs / Luisa Rey / Indian Party Guest / Ovid / Meronym

Jim Broadbent

Captain Molyneux / Vyvyan Ayrs / Timothy Cavendish / Korean Musician / Prescient 2

Hugo Weaving

Haskell Moore / Tadeusz Kesselring / Bill Smoke / Nurse Noakes / Boardman Mephi / Old Georgie

Jim Sturgess

Adam Ewing / Poor Hotel Guest / Megan's Dad / Highlander / Hae-Joo Chang / Adam / Zachry Brother-in-Law

Bae Doona

Tilda / Megan's Mom / Mexican Woman / Sonmi-451 / Sonmi-351 / Sonmi Prostitute

Ben Whishaw

Cabin Boy / Robert Frobisher / Store Clerk / Georgette / Tribesman

James D'Arcy

Young Rufus Sixsmith / Old Rufus Sixsmith / Nurse James / Archivist

Zhou Xun

Talbot / Hotel Manager / Yoona-939 / Rose

Keith David

Kupaka / Joe Napier / An-kor Apis / Prescient

Susan Sarandon

Madame Horrox / Older Ursula / Yusouf Suleiman / Abbess

Hugh Grant

Rev. Giles Horrox / Hotel Heavy / Lloyd Hooks / Denholme Cavendish / Seer Rhee / Kona Chief

David Gyasi

Autua / Lester Rey / Duophsyte

Robert Fyfe

Old Salty Dog / Mr. Meeks / Prescient 1

Martin Wuttke

Mr. Boerhaave / Guard / Leary the Healer

Robin Morrissey

Young Cavendish

Brody Nicholas Lee

Javier Gomez / Jonas / Zachry's Older Nephew

Ian van Temperley

Enforcer

Amanda Walker

Veronica

Ralph Riach

Ernie

Andrew Havill

Mr. Hotchkiss

Tanja de Wendt

Mrs. Hotchkiss

Raevan Lee Hanan

Little Girl with Orison at Papa Song's / Catkin / Zachry Relative

Götz Otto

Groundsman Withers

Niall Greig Fulton

Haskell Moore's Dinner Guest / Mozza Hoggins

Louis Dempsey

Haskell Moore's Dinner Guest / Jarvis Hoggins

Alistair Petrie

Haskell Moore's Dinner Guest / Musician / Felix Finch / Lascivious Businessman

Zhu Zhu

Megan Sixsmith / 12th Star Clone

Sylvestra Le Touzel

Haskell Moore's Dinner Guest / Nurse Judd / Aide in Slaughtership

Laura Vietzen

Young Ursula

Thomas Kügel

Vater

Marie Rönnebeck

Ursula's Daughter

Mya-Lecia Naylor

Miro

Katy Karrenbauer

Axwoman

Dulcie Smart

Ursula's Mother / Herbalist

Anna Holmes

Scientist / Executive

Shaun Lawton

Secretary

Moritz Berg

Porter

Heike Hanold-Lynch

Ms. Judd Look-a-like

Victor Solé

Mr. Roderick

Marco Albrecht

Scan Enforcer

David Mitchell

Union Spy

Jon Donahue

Moore's Accountant / Finch's Friend (uncredited)